His medical history included a 5-year history of well-controlled hypertension with regular review, childhood asthma and attention-deficit hyperactivity disorder (ADHD) diagnosed 4 years ago. The patient was afebrile and had no infective symptoms. Two days following vaccination, he presented to a hospital emergency department as he had a sudden onset dizziness, vertigo, ataxia, weakness of his right hand and constant diplopia, which led to a fall. In this report, we present a case of right-sided posterior inferior cerebellar stroke in a healthy patient who received his third (booster) dose of the Pfizer-BioNTech vaccine 1 day prior.Ī man in his late 30s developed sudden onset of sore neck, occipital headache, fatigue and leg cramps 1 day after receiving the third-dose (booster) of the Pfizer-BioNTech vaccine. These reports include vaccine-induced thrombotic thrombocytopaenia (VITT), repeated cardioembolic stroke, cerebral venous sinus thrombosis and other acute arterial thrombosis. 1 2 There have been a few reports of cerebrovascular accidents following vaccination, 3–11 though majority of these are following the first dose. The BNT162b2 (Pfizer-BioNTech) vaccine is an mRNA vaccine that encodes for the viral spike (S) protein of SARS-CoV-2, which has been approved for initial and booster dosing in Australia. It has been well established that there are numerous pathological consequences because of the disease itself, and this has led to the development of vaccines with novel technology. The COVID-19 pandemic has brought about a multitude of challenges and learning experiences for clinicians around the world. Further cases of stroke following administration of COVID-19 vaccine have been documented in the literature, but the association is yet to be established. Medical management with aspirin, statin therapy and rehabilitation led to the improvement of symptoms and enabled ongoing restoration of function. Due to the patient’s age and well-controlled risk factors, it was presumed to be a rare adverse effect of the vaccine. Full workup did not suggest other causes of the stroke. History and neurological examination suggested a posterior circulation stroke, which was confirmed by MRI, as a right-sided posterior inferior cerebellar artery stroke. A man in his late 30s developed acute neurological symptoms 2 days after receiving the booster dose of the BNT162b2 (Pfizer-BioNTech) mRNA COVID-19 vaccine. This report highlights a patient who developed stroke 2 days following the administration of the COVID-19 vaccine, although its association remains uncertain. As COVID-19 vaccination becomes widely available and administered globally, there have been several reports of side effects attributed to the vaccine.
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